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Dihydroergotamine Mesylate, Injection

(En español, presione aquí)

 What are other names for this medicine?
 What is this medicine used for?
 What should my healthcare provider know before I take this medicine?
 How do I use it?
 What if I overdose?
 What should I watch out for?
 What are the possible side effects?
 What products might interact with this medicine?
 How should I store this medicine?

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Pronunciation: dy-hy-droh-er-GOT-a-meen MESS-i-late

What are other names for this medicine?

Type of medicine: antimigraine

Generic and brand names: dihydroergotamine mesylate, injection; D.H.E. 45

What is this medicine used for?

This medicine is given by injection (shots) to relieve the pain of migraine and cluster headaches. This medicine does not work for other types of headaches.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

If you take this medicine with certain drugs that affect the liver, it can have very serious effects on blood supply to the hands, feet, and brain. This medicine may interact with many other medicines. Tell your provider all prescription and nonprescription medicines you take. Do not start or stop any medicine unless you check with your healthcare provider or pharmacist first.

Females of childbearing age: Do not use this medicine if you are pregnant. This medicine has been reported to cause birth defects. Use an effective birth control method while you are taking this medicine. Stop taking this medicine at the first sign that you may be pregnant and contact your healthcare provider right away. Do not breast-feed while you are using this medicine.

How do I use it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more or take it longer than prescribed. It is not taken on a regular schedule.

The shots are most effective when given at the first sign of a migraine. Your healthcare provider may give you the injection.

Do not take more than 6 mL in any 7-day period unless your healthcare provider specifically tells you to do so. If you are giving yourself these shots, follow the directions that come with the medicine package. Be sure you stay within the dosage limits. Ask your healthcare provider or pharmacist about anything you do not understand.

Do not use any other medicine for migraines within 24 hours of using this medicine.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: nausea, vomiting, weakness, muscle pain, numbness or tingling in your fingers or toes, drowsiness, confusion, seizures.

What should I watch out for?

You should not use this medicine for more than 10 days per month. Taking too much of this medicine, or taking it too often, can cause overuse or rebound headaches. Tell your healthcare provider if you need to use the medicine more often, if the medicine is not working as well, if you have headaches more often, or if your headaches get worse.

Do not smoke while using this medicine. Smoking may increase your risk of side effects.

This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.

This medicine may make you more sensitive to cold temperatures. Dress warmly during cold weather and avoid prolonged exposure to cold temperatures.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are using this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Numbness and tingling in fingers or toes; cold hands or feet; muscle pain or weakness in arms or legs; chest pain, irregular heartbeat.

Other: Nausea, vomiting, diarrhea, sweating, flushing, dizziness, drowsiness, soreness where injection was given.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

Do not eat grapefruit or drink grapefruit juice while taking this medicine.

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

____________________________________________________

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

healthinformatics info

References

Dihydroergotamine mesylate Injection. Bedford Laboratories. U.S. National Library of Medicine, National Institutes of Health, DailyMed. Accessed February 25, 2013 from http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=06befe05-e96d-4b86-bb97-484593cce3e8

Dihydroergotamine. Clinical Pharmacology Online, 2013 Elsevier/Gold Standard. Accessed February 25, 2013, from http://clinicalpharmacology-ip.com.ezproxy.samford.edu/Forms/drugoptions.aspx?cpnum=192&n=Dihydroergotamine&t=0

Dihydroergotamine. Lexi-Comp ONLINE. 2013 Lexi-Comp, Inc. Accessed February 25, 2013 from http://www.crlonline.com.ezproxy.samford.edu/lco/action/doc/retrieve/docid/patch_f/6750



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Last Modified: 2014-02-14

Last Reviewed: 2013-02-25

Website Updated: October 2014

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This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.


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